Principles of Evolution, Ecology and Behavior

Yale , Prof.Stephen C. Stearns

LECTURE21 :

Evolutionary Medicine

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Lecture Description

Principles of Evolution, Ecology and Behavior (EEB 122)Evolution plays an important though underutilized role in medicine. Evolution guides how our bodies respond to various treatments, how pathogens will respond to treatments, and how pathogens' responses will change over time. Pathogens oftentimes will evolve to an intermediate level of virulence where they become strong enough to infect a host and reproduce, but not so strong as to kill the host before it can spread the pathogen.00:00 - Chapter 1. Introduction 06:40 - Chapter 2. "Thrifty Phenotypes" 11:36 - Chapter 3. Auto-immune Diseases in Developed and Undeveloped Countries 17:27 - Chapter 4. Treating Auto-immune Diseases 26:20 - Chapter 5. Pathogen Evolution 37:40 - Chapter 6. Virulence 47:16 - Chapter 7. SummaryComplete course materials are available at the Open Yale Courses website: http://open.yale.edu/coursesThis course was recorded in Spring 2009.

Course Description

The Nature of Evolution: Selection, Inheritance, and History – Basic Transmission Genetics – Adaptive Evolution: Natural Selection – Neutral Evolution: Genetic Drift – How Selection Changes the Genetic Composition of Population – The Origin and Maintenance of Genetic Variation – The Importance of Development in Evolution – The Expression of Variation: Reaction Norms – The Evolution of Sex – Genomic Conflict – Life History Evolution – Sex Allocation – Sexual Selection – Species and Speciation – Phylogeny and Systematics – Comparative Methods: Trees, Maps, and Traits – Key Events in Evolution – Major Events in the Geological Theatre – The Fossil Record and Life’s History – Coevolution – Evolutionary Medicine – The Impact of Evolutionary Thought on the Social Sciences – The Logic of Science – Climate and the Distribution of Life on Earth – Interactions with the Physical Environment – Population Growth: Density Effects – Interspecific Competition – Ecological Communities – Island Biogeography and Invasive Species – Energy and Matter in Ecosystems – Why So Many Species? The Factors Affecting Biodiversity – Economic Decisions for the Foraging Individual – Evolutionary Game Theory: Fighting and Contests – Mating Systems and Parental Care – Alternative Breeding Strategies – Selfishness and Altruism

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