Freshman Organic Chemistry

Yale,, Fall 2008 , Prof. J. Michael McBride

Updated On 02 Feb, 19


How Do You Know - Force Laws, Lewis Structures and Resonance - Double Minima, Earnshaws Theorem and Plum - Puddings - Coping with Smallness and Scanning Probe Microscopy - X-Ray Diffraction-Seeing Bonds by Electron Difference Density - Quantum Mechanical Kinetic Energy - One-Dimensional Wave Functions - Chladni Figures and One - Electron Atoms - Reality and the Orbital Approximation - Orbital Correction and Plum - Pudding Molecules - Overlap and Atom - Pair Bonds - Overlap and Energy - Match - Checking Hybridization Theory with XH_3-Chemical Reactivity: SOMO, HOMO, and LUMO - Recognizing Functional Groups - Reaction Analogies and Carbonyl Reactivity - Amide, Carboxylic Acid and Alkyl Lithium-Oxygen and the Chemical Revolution - Rise of the Atomic Theory - Berzelius to Liebig and W�hler - Radical and Type Theories (1832-1850)-Valence Theory and Constitutional Structure (1858) - Determining Chemical Structure by Isomer Counting (1869)

Models in 3D Space (1869-1877); Optical Isomers - Vant Hoffs Tetrahedral Carbon and ChiralityCommunicating Molecular Structure in Diagrams and Words - Stereochemical Nomenclature; Racemization and Resolution - Preparing Single Enantiomers and the Mechanism of Optical Rotation - Esomeprazole as an Example of Drug Testing and Usage - Preparing Single Enantiomers and Conformational Energy - Stereotopicity and Baeyer Strain Theory -Conformational Energy and Molecular Mechanics - Sharpless Oxidation Catalysts and the Conformation of Cycloalkanes - Understanding Molecular Structure and Energy through Standard Bonds - Bond Energies, the Boltzmann Factor and Entropy - Potential Energy Surfaces, Transition State Theory and Reaction Mechanism


Lecture 37: Potential Energy Surfaces, Transition State Theory and Reaction Mechanism

4.1 ( 11 )

Lecture Details

Freshman Organic Chemistry (CHEM 125)

After discussing the statistical basis of the law of mass action, the lecture turns to developing a framework for understanding reaction rates. A potential energy surface that associates energy with polyatomic geometry can be realized physically for a linear, triatomic system, but it is more practical to use collective energies for starting material, transition state, and product, together with Eyring theory, to predict rates. Free-radical chain halogenation provides examples of predicting reaction equilibria and rates from bond dissociation energies. The lecture concludes with a summary of the semesters topics from the perspective of physical-organic chemistry.

0000 - Chapter 1. The Boltzmann Factor and Entropy Against Traditional Views on Society
0740 - Chapter 2. The Statistical Basis of the Law of Mass Action
1313 - Chapter 3. Understanding Reaction Rates The Potential Energy Surface and Collective Energies
2940 - Chapter 4. Free Radical Halogenations Predicting Reaction Equilibria and Rates
4301 - Chapter 5. A Summary of the First Semester

Complete course materials are available at the Open Yale Courses website httpopen.yale.educourses

This course was recorded in Fall 2008.



4 Ratings
comment person image


Excellent course helped me understand topic that i couldn't while attendinfg my college.

comment person image


Great course. Thank you very much.