Freshman Organic Chemistry
Yale,, Fall 2008 , Prof. J. Michael McBride
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Updated On 02 Feb, 19
How Do You Know - Force Laws, Lewis Structures and Resonance - Double Minima, Earnshaws Theorem and Plum - Puddings - Coping with Smallness and Scanning Probe Microscopy - X-Ray Diffraction-Seeing Bonds by Electron Difference Density - Quantum Mechanical Kinetic Energy - One-Dimensional Wave Functions - Chladni Figures and One - Electron Atoms - Reality and the Orbital Approximation - Orbital Correction and Plum - Pudding Molecules - Overlap and Atom - Pair Bonds - Overlap and Energy - Match - Checking Hybridization Theory with XH_3-Chemical Reactivity: SOMO, HOMO, and LUMO - Recognizing Functional Groups - Reaction Analogies and Carbonyl Reactivity - Amide, Carboxylic Acid and Alkyl Lithium-Oxygen and the Chemical Revolution - Rise of the Atomic Theory - Berzelius to Liebig and W�hler - Radical and Type Theories (1832-1850)-Valence Theory and Constitutional Structure (1858) - Determining Chemical Structure by Isomer Counting (1869)
Models in 3D Space (1869-1877); Optical Isomers - Vant Hoffs Tetrahedral Carbon and ChiralityCommunicating Molecular Structure in Diagrams and Words - Stereochemical Nomenclature; Racemization and Resolution - Preparing Single Enantiomers and the Mechanism of Optical Rotation - Esomeprazole as an Example of Drug Testing and Usage - Preparing Single Enantiomers and Conformational Energy - Stereotopicity and Baeyer Strain Theory -Conformational Energy and Molecular Mechanics - Sharpless Oxidation Catalysts and the Conformation of Cycloalkanes - Understanding Molecular Structure and Energy through Standard Bonds - Bond Energies, the Boltzmann Factor and Entropy - Potential Energy Surfaces, Transition State Theory and Reaction Mechanism
4.1 ( 11 )
Freshman Organic Chemistry (CHEM 125)
Professor McBride uses a hexagonal "benzene" pattern and Franklins X-ray pattern of DNA, to continue his discussion of X-ray crystallography by explaining how a diffraction pattern in "reciprocal space" relates to the distribution of electrons in molecules and to the repetition of molecules in a crystal lattice. He then uses electron difference density mapping to reveal bonds, and unshared electron pairs, and their shape, and to show that they are only one-twentieth as dense as would be expected for Lewis shared pairs. Anomalous difference density in the carbon-fluorine bond raises the courses second great question, "Compared to what?"
0000 - Chapter 1. Understanding Diffraction Patterns Continuing the Case of the Hexagonal "Benzene"
1510 - Chapter 2. Double Helices and DNA Even and Offset Planes
2904 - Chapter 3. Revealing Bonds and Unshared Electron Pairs via Electron Difference Density Maps
4323 - Chapter 4. The Second Great Question "Compared with What?"
Complete course materials are available at the Open Yale Courses website httpopen.yale.educourses
This course was recorded in Fall 2008.
Sep 12, 2018
Excellent course helped me understand topic that i couldn't while attendinfg my college.
March 29, 2019
Great course. Thank you very much.