Frontiers of Biomedical Engineering

Yale Course , Spring 2008 , Prof. W. Mark Saltzman

101 students enrolled

Overview

Biomedical Engineering, Genetic Engineering, Cell Culture Engineering, Bio-molecular Engineering, Cardiovascular Physiology, Renal Physiology, Biomechanics and Orthopedics, Bioimaging, Tissue Engineering.

Lecture 11: Biomolecular Engineering General Concepts - I

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        Lecture Details

        Professor Saltzman starts the lecture with an introduction to pharmacokinetics and pharmacodynamics. Professor Saltzman talks about the concept of dose-response. He introduces different routes of drug administration and how they affect drug distribution and bioavailability (i.e., intravenous, oral, and sublingual routes). First-pass drug metabolism by the liver is also identified as an important source of drug degradation. Finally, modeling the body as a well-stirred vessel, Professor Saltzman explains the first-order rate equation C = (M0V)e-kt, that can be used calculate the amount of drug in the body (M) as a function of time (t) and a rate constant (k); and the equation for drug half-life t = ln(2k).

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