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Frontiers of Biomedical Engineering

Yale,, Spring 2008 , Prof. W. Mark Saltzman

Updated On 02 Feb, 19

Overview

Biomedical Engineering, Genetic Engineering, Cell Culture Engineering, Bio-molecular Engineering, Cardiovascular Physiology, Renal Physiology, Biomechanics and Orthopedics, Bioimaging, Tissue Engineering.

Includes

Lecture 12: Biomolecular Engineering General Concepts - II

4.1 ( 11 )


Lecture Details

Professor Saltzman reviews the pharmacokinetic first-order rate equation that can be used to model changes in drug concentration in the blood, as well as its derivation from the law of conservation of mass. The importance of maintaining a drug concentration that is sufficient for therapeutic purpose, but below a toxic level, is emphasized. Since this is directly affected by drug administration method, ways to localize and sustain therapeutic concentrations of drug, such as incorporating in slow-releasing, biocompatible polymers are introduced. Professor Saltzman gave some examples of clinical applications of controlled release drug delivery system, such as anti-restenosis drug incorporated into stents, and chemotherapeutic drugs in brain implants and microspheres.

Ratings

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Comments
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Sam

Excellent course helped me understand topic that i couldn't while attendinfg my college.

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Dembe

Great course. Thank you very much.

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