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NMR spectroscopy for Chemists and Biologists

IIT Bombay, , Prof. Prof. Ashutosh Kumar

Updated On 02 Feb, 19

Overview

This course will start with Basic principles of NMR, walk through the analysis of spectra and demonstrate the application of multidimensional NMR spectroscopy in Chemistry and structural Biology.

Includes

Lecture 1: Lecture 1 : Basic concepts

4.1 ( 11 )

Lecture Details

Course Details

COURSE LAYOUT

Week 1 :
  • Nuclear Spin and Magnetic Moments 
  • Nuclear Spins in a Magnetic Field Spin 
  • Lattice Relaxation Spin temperature Resonance 
  • Absorption of Energy and The NMR Experiment Resonance 
  • Absorption of Energy and The NMR Experiment Kinetics of Resonance Absorption
Week 2 :
  • Selection Rules and Line widths 
  • Bloch equations
  • More about relaxation 
  • More about relaxation Sensitivity
Week 3 :
  • Instruction to operator Algebra 
  • Chemical Shift
  • Anisotropy of chemical shifts Learning spectral simulation 
Week 4 :
  • Factors Influencing Isotropic Chemical shifts: Spin Spin Coupling 
  • Analysis of NMR spectra of molecules 
  • Learning spectral simulation
Week 5 :
  • Dynamic Effects in the NMR spectra : Two site exchange
  • Collapse of spin multiplets
  • Conformational Averaging of J- values
  • Analysis of NMR spectra of molecules with J Values 
Week 6 :
  • Principles of Fourier transform
  • NMR Theorems on Fourier transforms
  • Practical aspects of recording FTNMR spectra
  • Free Induction Decay (FID) and the spectrum
  • Pulse repetition rate
  • Folding of signals
  • Acquisition time and the resolution
  • Data processing in FT
  • NMR Learning of Data processing 
Week 7 :
  • Dynamic range in FTNMR and solvent suppression
  • The Nuclear Overhauser Effect - Experimental Schemes,Advanced Treatment
  • Steady state NOE and Transient NOE 
Week 8 :
  • Spin Echo Uncoupled spins
  • Spin Echo Coupled spins
  • Spin-lattice relaxation
  • Spin-spin relaxation
  • Polarization transfer SPT and INEPT spectral simulation
Week 9 :
  • Density matrix, Elements of Density Matrix, Time evolution of density operator 
  • Time evolution of density operator 
  • Product operator formalism 
Week 10 :
  • Segmentation of the time axis
  • Two dimensional NMR 2D
  • Fourier Transformation in NMR
  • Peak shapes in 2D spectrum
  • Quadrature detection in two-dimensional NMR 
Week 11 :
  • 2D- resolution/ separation experiments
  • Two-dimensional correlation experiments COSY, TDQ-COSY etc TOCSY
Week 12 :
  • 2D NOESY, 2D ROESY, Heteronuclear COSY,
  • The HETCOR pulse sequence HSQC 


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Comments
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Sam

Sep 12, 2018

Excellent course helped me understand topic that i couldn't while attendinfg my college.

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Dembe

March 29, 2019

Great course. Thank you very much.

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