Introduction to Biomaterials

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Introduction to basic concepts of Materials Science; Salient properties of important material classes – Property requirement of biomaterials; Concept of biocompatibility – Structure and properties of biological cells & tissues – Cell-material interactions and foreign body response – Assessment of biocompatibility of biomaterials – In vitro biochemical assays (cellular adhesion, cellular viability using MTT, osteogenic differentiation using ALP assay; Biomnuneralisation using Osteocalcin assay) – In vivo testing and histocompatibility assessment – Genotoxicity assessment (Physical damage to DNA by biomaterial eluates) – Important biometallic alloys: Ti-based, stainless steels, Co-Cr-Mo alloys – Bioinert, Bioactive and bioresorbable ceramics – Processing and properties of different bioceramic materials with emphasize on hydroxyapatite – Synthesis of biocompatible coatings on structural implant materials – Plasma spraying of carbon nanotube reinforced hydroxyapatite on Ti-6Al-4V substrate; in-vitro cytocompatibility – Microstructure and properties of glass-ceramics – Biodegradable polymers – Design concept of developing new materials for bio-implant applications.

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