Introduction to Biomaterials

Overview

Contents:
Introduction to basic concepts of Materials Science; Salient properties of important material classes - Property requirement of biomaterials; Concept of biocompatibility - Structure and properties of biological cells & tissues - Cell-material interactions and foreign body response - Assessment of biocompatibility of biomaterials - In vitro biochemical assays (cellular adhesion, cellular viability using MTT, osteogenic differentiation using ALP assay; Biomnuneralisation using Osteocalcin assay) - In vivo testing and histocompatibility assessment - Genotoxicity assessment (Physical damage to DNA by biomaterial eluates) - Important biometallic alloys: Ti-based, stainless steels, Co-Cr-Mo alloys - Bioinert, Bioactive and bioresorbable ceramics - Processing and properties of different bioceramic materials with emphasize on hydroxyapatite - Synthesis of biocompatible coatings on structural implant materials - Plasma spraying of carbon nanotube reinforced hydroxyapatite on Ti-6Al-4V substrate; in-vitro cytocompatibility - Microstructure and properties of glass-ceramics - Biodegradable polymers - Design concept of developing new materials for bio-implant applications.